2022 Mercedes-Benz E 350 Problems, Complaints & Recalls

Source: NHTSA · Updated Oct 10, 2026 · 9 owner complaints analyzed

Compared with other E 350 years
Not enough data 15th of 22 for complaints
NHTSA crash rating
Not rated

Owners have filed 9 complaints with NHTSA about the 2022 Mercedes-Benz E 350. That ranks 15th out of 22 E 350 model years for complaints. The most reported problem area is forward collision avoidance (3 complaints, 33%). There are 3 safety recalls covering this model year.

Complaints are unverified owner reports and are not adjusted for sales volume.

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Most common 2022 Mercedes-Benz E 350 problems

Complaints grouped by the part of the car owners reported, with the median mileage when the problem happened.

Forward Collision Avoidance3
Unknown or Other3
Electrical System1
Fuel System, Gasoline1 · ~14,403 mi
Power Train1
Vehicle Speed Control1
Visibility/wiper1
Problem areaComplaintsShareMedian milesOwners mention mostTypical repair cost
Forward Collision Avoidance333%———
Unknown or Other333%———
Electrical System111%———
Fuel System, Gasoline111%14,403——
Power Train111%———
Vehicle Speed Control111%———
Visibility/wiper111%———

One complaint can list several problem areas, so shares can add up to more than 100%.

Complaints by year received

Peak: 2023, with 3 complaints
2023: 3202332024: 2202422025: 1202512026: 320263

n = 9 complaints · Source: NHTSA

2022 Mercedes-Benz E 350 recalls (3)

Tap a recall to see the problem, the risk and the fix.

Fuel system, gasoline:delivery:fuel pumpDec 21, 2023 · NHTSA campaign 23V880000 · 79,676 vehicles

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.

Risk: A loss of drive power can increase the risk of a crash.

Fix: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.

Fuel system, gasoline:delivery:fuel pumpJun 26, 2023 · NHTSA campaign 23V445000 · 143,551 vehicles

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

Risk: A loss of drive power can increase the risk of a crash.

Fix: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

Steering: steering wheel/handle barMar 25, 2022 · NHTSA campaign 22V189000 · 8,396 vehicles

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.

Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.

Fix: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.

To see whether a specific car still has an open recall, enter its VIN on NHTSA's official recall lookup. You can also decode a VIN here.

Recent owner reports

Short excerpts of the latest complaints filed with NHTSA, with personal details removed. Full reports can be searched on NHTSA.gov.

2022 Mercedes-Benz E350 with Driver Assistance Package. Two incidents of uncommanded automatic braking with no vehicle ahead and no debris on the road: (1) October 7, 2026, 4:30 AM — Active Brake Assist braked automatically on a clear road in dark conditions; (2) second incident of the same kind…

Forward Collision Avoidance · received Oct 10, 2026 · NHTSA complaint 11770360

I own a 2022 Mercedes-Benz E350. The front glass roof panel located directly above the windshield developed a large crack while the vehicle was parked. The crack extends nearly the full length of the panel and includes areas where the glass has separated along the fracture. I am not aware of any…

Visibility/wiper · received Jul 22, 2026 · NHTSA complaint 11752247

This vehicle on an ongoing basis is reporting false speed limits. It consistently abruptly drops the indicated speed limit from 70MPH on [XXX] northbound in Salt Lake City. the vehicle slows itself abruptly in traffic that is sometimes dense and traveling 70 to 80. An eventual rear end collision…

Vehicle Speed Control · received Jan 7, 2026 · NHTSA complaint 11709449

Major issue found with engine cylinder head in various models with 2.0 Liter Turbo charged engines (Engine code M260 or M264). Cylinder heads have premature wear at valve seats, causing engine misfires and unsafe driving conditions. (Sudden loss of power, even on freeways.) Mercedes-Benz had…

Power Train · received Oct 23, 2025 · NHTSA complaint 11695193

On June 16, 2024, while driving my 2022 Mercedes E 350 with my two young children in the car, my sunroof suddenly and literally exploded. Fortunately, the sunroof screen was closed, which prevented us from sustaining any direct injuries. However, the entire sunroof shattered and is now gone. The…

Unknown or Other · received Jun 18, 2024 · NHTSA complaint 11595117

Other Mercedes-Benz E 350 years

← 2021 E 350 · 2023 E 350 →

See all Mercedes-Benz E 350 problems by year, every Mercedes-Benz model, or the Mercedes-Benz VIN decoder.

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Frequently asked questions

What are the most common problems with the 2022 Mercedes-Benz E 350?

Owners most often report forward collision avoidance, unknown or other, electrical system problems. The top one, forward collision avoidance, accounts for 3 complaints.

Was there a recall on the 2022 Mercedes-Benz E 350?

Yes, 3 safety recalls. Enter your VIN at NHTSA.gov to check whether the repairs were done on your car.

Was the 2022 Mercedes-Benz E 350 a good year?

Complaint data can't fully answer that, because counts aren't adjusted for sales. Compared with other E 350 model years, the 2022 has too little data to compare. Always get a pre-purchase inspection and check the VIN for open recalls.