2006 Mercedes-Benz E350 Problems, Complaints & Recalls

Source: NHTSA · Updated Sep 23, 2026 · 399 owner complaints analyzed

Compared with other E350 years
Far more complaints than other years 1st of 22 for complaints
NHTSA crash rating
Not rated

Owners have filed 399 complaints with NHTSA about the 2006 Mercedes-Benz E350. That is the most of any E350 model year in the database (22 years). The most reported problem area is fuel/propulsion system (144 complaints, 36%), typically at around 96,750 miles. Complaints mention 14 crashes, 9 fires, 18 injuries. There are 4 safety recalls covering this model year. NHTSA has opened 2 defect investigations involving it.

Complaints are unverified owner reports and are not adjusted for sales volume.

Compare with another car

Most common 2006 Mercedes-Benz E350 problems

Complaints grouped by the part of the car owners reported, with the median mileage when the problem happened.

Fuel/propulsion System144 · ~96,750 mi
Fuel System, Gasoline78 · ~84,006 mi
Engine50 · ~111,000 mi
Service Brakes46 · ~131,000 mi
Power Train37 · ~72,740 mi
Engine and Engine Cooling22 · ~66,215 mi
Electrical System19 · ~66,750 mi
Air Bags13 · ~86,605 mi
Unknown or Other10 · ~72,488 mi
Service Brakes, Hydraulic7 · ~139,893 mi
Problem areaComplaintsShareMedian milesOwners mention mostTypical repair cost
Fuel/propulsion System problems14436%96,750“fuel tank” (28%)$4,000
Fuel System, Gasoline problems7820%84,006“fuel tank” (38%)$2,850
Engine problems5013%111,000“balance shaft” (18%)$7,600
Service Brakes4612%131,000——
Power Train379%72,740——
Engine and Engine Cooling226%66,215——
Electrical System195%66,750——
Air Bags133%86,605——
Unknown or Other103%72,488——
Service Brakes, Hydraulic72%139,893——
Vehicle Speed Control72%30,290——
Steering62%125,663——
Electronic Stability Control (esc)51%107,000——
Exterior Lighting51%76,365——
Structure51%85,000——
Tires51%29,500——
Suspension41%92,300——
Visibility41%94,000——
Visibility/wiper41%124,220——
Forward Collision Avoidance21%———
Seats21%62,697——
Wheels21%34,050——
Equipment10%———
Equipment Adaptive/mobility10%40,000——
Traction Control System10%129,000——

One complaint can list several problem areas, so shares can add up to more than 100%.

Complaints by year received

Peak: 2014, with 76 complaints
2005: 420052006: 22007: 520072008: 42009: 520092010: 112011: 2520112012: 352013: 6520132014: 76762015: 4420152016: 182017: 3320172018: 102019: 1320192020: 182021: 1120212022: 92023: 320232024: 32025: 420252026: 1

n = 399 complaints · Source: NHTSA

2006 Mercedes-Benz E350 recalls (4)

Tap a recall to see the problem, the risk and the fix.

Visibility:sun/moon roof assemblyNov 19, 2024 · NHTSA campaign 24V874000 · 33,456 vehicles

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2001-2011 C-Class, CLK, E-Class, and CLS vehicles. Please see the recall report for a complete list of models and model years. The glass sunroof panel may not be properly secured and can detach.

Risk: A detached sunroof panel can become a road hazard, increasing the risk of a crash.

Fix: Dealers will inspect and replace the sunroof panel as necessary, free of charge. Owner notification letters were mailed January 10, 2025. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of previous NHTSA recall number 22V-954. MBUSA's number for this recall is 2024120001/2/3.

Visibility:sun/moon roof assemblyDec 23, 2022 · NHTSA campaign 22V954000 · 131,653 vehicles

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2001-2011 C-Class, CLK, E-Class, and CLS vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The glass sunroof panel may not be properly secured and may detach.

Risk: A detached sunroof panel may become a road hazard, increasing the risk of a crash.

Fix: Dealers will inspect and replace the sunroof panel as necessary free of charge. Owner notification letters were mailed February 3, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. This recall expands NHTSA recall number 19V-918. MBUSA's numbers for this recall are 2023010004, 2023010005, and 2023010006.

Visibility:sun/moon roof assemblyMar 19, 2021 · NHTSA campaign 21V196000 · 11,356 vehicles

Problem: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2006-2007 C350, C230, C280, CLK350, E320CDI, E350 Wagon, E350, 2006 C55 AMG, CLK500, CLS500, CLS55 AMG, E500 Wagon, E500, E55 AMG, 2007 CLK550, CLS550, CLS63 AMG, E550, E63 AMG, and E63 Wagon AMG vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly causing the glass panel to detach from the vehicle.

Risk: A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.

Fix: MBUSA will notify owners, and dealers will inspect the glass panel bonding and replace the sliding roof, as necessary, free of charge. Owner letters were mailed May 7, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of recall number 19V-918. MBUSA's number for this recall is 2021040012.

Visibility:sun/moon roof assemblyDec 20, 2019 · NHTSA campaign 19V918000 · 747,928 vehicles

Problem: Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2001-2011 vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly resulting in the glass panel detaching from the vehicle. For a full list of the affected models visit: https://static.nhtsa.gov/odi/rcl/2019/RMISC-19V918-4126.pdf

Risk: A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.

Fix: MBUSA will notify owners, and dealers will inspect the glass panel bonding and replace the sliding roof, as necessary, free of charge. The recall began July 10, 2020. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2020040011.

To see whether a specific car still has an open recall, enter its VIN on NHTSA's official recall lookup. You can also decode a VIN here.

NHTSA defect investigations

  • Fuel Leakage From The Fuel Tank (EA13003) — opened Mar 15, 2013, closed Dec 19, 2014.
  • Driver Air Bag Circuit High Resistance (PE10017) — opened May 14, 2010, closed Nov 24, 2010.

Recent owner reports

Short excerpts of the latest complaints filed with NHTSA, with personal details removed. Full reports can be searched on NHTSA.gov.

The contact owns a 2006 Mercedes-Benz E-350. The contact stated that the sensotronic brake control warning was illuminated. The contact researched and found information about warranty coverage for 2006-2010 models with a 25-year warranty. The vehicle was taken to the dealer, who diagnosed that the…

Service Brakes, Hydraulic · received Sep 23, 2026 · NHTSA complaint 11766341

Mercedes Benz issued a recall and extended a warranty on its 2003-2005 E Class SBC braking systems (recall # [redacted]) and extended the warranty to 25 years; the 2006 E Class models have the exact same SBC braking system but is not included in the recall. Mercedes needs to add the 2006 E Class…

Service Brakes · received Dec 3, 2025 · NHTSA complaint 11702819

The contact called on behalf of the owner of a 2006 Mercedes-Benz E350. The contact stated that while his mother was driving at an undisclosed speed and approaching a traffic light, the brake pedal was depressed; however, the brakes failed to function as intended. The brake pedal was depressed down…

Service Brakes, Hydraulic · received Oct 23, 2025 · NHTSA complaint 11695309

The contact's son owns a 2006 Mercedes-Benz E350. The contact stated that while his son was driving at an undisclosed speed, the sunroof detached and shattered on the roadway. The vehicle was not taken to the dealer or an independent mechanic. The vehicle was not repaired. After investigating the…

Visibility · received Oct 21, 2025 · NHTSA complaint 11694784

Reduce power braking depress brake fully keeps popping up on my dash and not letting me take it out of gear

Unknown or Other · received May 30, 2025 · NHTSA complaint 11663896

Other Mercedes-Benz E350 years

← 2005 E350 · 2007 E350 →

See all Mercedes-Benz E350 problems by year, every Mercedes-Benz model, or the Mercedes-Benz VIN decoder.

Similar Mercedes-Benz models

Embed this 2006 Mercedes-Benz E350 badge on your site

Copy this code into your blog or forum post. It shows live complaint and recall counts and links back here.

Frequently asked questions

What are the most common problems with the 2006 Mercedes-Benz E350?

Owners most often report fuel/propulsion system, fuel system, gasoline, engine problems. The top one, fuel/propulsion system, accounts for 144 complaints.

Was there a recall on the 2006 Mercedes-Benz E350?

Yes, 4 safety recalls. Enter your VIN at NHTSA.gov to check whether the repairs were done on your car.

Was the 2006 Mercedes-Benz E350 a good year?

Complaint data can't fully answer that, because counts aren't adjusted for sales. Compared with other E350 model years, the 2006 has far more complaints than most years. Always get a pre-purchase inspection and check the VIN for open recalls.