2006 Mercedes-Benz E350 Engine Problems
Owners have filed 50 complaints with NHTSA about engine problems on the 2006 Mercedes-Benz E350, 13% of all complaints for this model year. Half of the reports with a mileage happened before 111,000 miles. The words owners use most often: “balance shaft” (18% of reports).
- 50engine complaints
- 111,000median miles at failure
- 4mention a crash
- 3mention an injury
- 0related recalls
- $7,600typical repair cost reported by owners
- 22%of reports with a speed happened at 50+ mph
What owners describe
Phrases that appear unusually often in these complaints compared with complaints about other cars.
- Balance shaft: mentioned in 9 of 50 complaints (18%)
- Class action: mentioned in 5 of 50 complaints (10%)
- Timing chain: mentioned in 5 of 50 complaints (10%)
How much does it cost to fix?
Owners who wrote down what they paid or were quoted put the typical engine repair on the 2006 Mercedes-Benz E350 at $7,600, and half of them between $5,700 and $9,800.
Based on 5 NHTSA complaints about this problem alone that state a repair bill or quote (2012–2022), converted to 2026 dollars with the U.S. consumer price index. These are owners' own figures, not a quote: they include dealer quotes, and owners who file complaints often faced larger repairs, so they can run higher than typical shop prices. Prices vary by shop, region and warranty coverage. How we calculate this.
At what mileage do engine problems happen?
Based on 34 complaints that reported the odometer reading.
How serious are the reports?
Of 50 complaints, 4 mention a crash, 2 a fire, 3 an injury.
Mercedes-Benz E350 engine complaints by model year
| Model year | Engine complaints | Share of that year | Median miles |
|---|---|---|---|
| 2025 E350 | 1 | 50% | — |
| 2021 E350 | 4 | 31% | — |
| 2020 E350 | 3 | 38% | — |
| 2017 E350 | 2 | 29% | — |
| 2016 E350 | 5 | 10% | 41,500 |
| 2015 E350 | 2 | 6% | 50 |
| 2014 E350 | 20 | 7% | 23,650 |
| 2013 E350 | 15 | 9% | 39,536 |
| 2012 E350 | 20 | 9% | 61,781 |
| 2011 E350 | 13 | 6% | 90,000 |
| 2010 E350 | 15 | 8% | 59,948 |
| 2009 E350 | 5 | 8% | 45,000 |
| 2008 E350 | 13 | 8% | 115,500 |
| 2007 E350 | 28 | 8% | 93,623 |
| 2006 E350 | 50 | 13% | 111,000 |
When owners reported it
Related recalls (0)
No safety recall lists engine for the 2006 Mercedes-Benz E350. A pattern of complaints does not always lead to a recall.
What owners report
Short excerpts of recent complaints, with personal details removed. Full reports are on NHTSA.gov.
The engine in these cars are defective and can cause serious harm due to a part that was put inside the motor made of plastic. There was a lawsuit but if you didnât get in on it you losses out for not knowing. I was recently at Mercedes dealership to fix recalls and they brushed me off. The car…
Certain Mercedes-Benz models 2005- 2007 M272 V6 and M273 V8âs have faced or are facing issues regarding the balance sprocket in which drives the camshaft and crankshaft of the vehicle. Mercedes-Benz had made a decision to make certain engine components out of soft metals, when such metals are not…
Engine codes P0016 and P0017 reads cam shaft and crank shaft correlation it is everywhere on the internet and on the Mercedes Benz Forum.This is a know problem that Mercedes has ignored. its on all 2004 thru 2008 vehicles with the 3.5 engine. Calls for a balancer shaft replacement. This should…
Frequently asked questions
Do all 2006 Mercedes-Benz E350s have engine problems?
No. NHTSA has 50 owner complaints about engine for the 2006 Mercedes-Benz E350 (13% of the 399 complaints for this model year). Complaint data shows that the problem is reported, not how many of all cars sold are affected.
Was there a recall on the 2006 Mercedes-Benz E350 engine?
No recall currently lists engine for this vehicle.
At what mileage do engine problems start?
The median reported mileage is 111,000 miles: half of the reports with a mileage came before that.
How much does it cost to fix engine problems on the 2006 Mercedes-Benz E350?
Owners report a typical cost of $7,600 (half paid between $5,700 and $9,800), from 5 complaints that state a repair bill or quote, in 2026 dollars.
What do owners say about engine problems on the 2006 Mercedes-Benz E350?
The most frequent phrase is “balance shaft”, in 9 of 50 complaints, followed by “class action” (5).
Other 2006 Mercedes-Benz E350 problems
See all 2006 Mercedes-Benz E350 problems or engine problems across all E350 years.